| Lesson | Topic | Statement(s) and Objective(s) | Activities |
| 1 | Genes | 3.1.U1: A gene is a heritable factor that consists of a length of DNA and influences a specific characteristic.
3.1.U2: A gene occupies a specific position on a chromosome.
3.1.A2: Comparison of the number of genes in humans with other species.
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Location of disease genes activity A&B: newest human gene tally (questions) Scitable: Analyzing gene function A&B: Telling Jewels From Junk in DNA (questions) A&B: The Complex Truth About 'Junk DNA' |
| 2 | Alleles | 3.1.U3: The various specific forms of a gene are alleles.
3.1.U4: Alleles differ from each other by one or only a few bases.
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A&B: Uncommon Carriers (questions) |
| 3 | Mutations | 3.1.U5: New alleles are formed by mutation
3.1.A1: The causes of sickle cell anemia, including a base substitution mutation, a change to the base sequence of mRNA transcribed from it and a change to the sequence of a polypeptide in hemoglobin.
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View sickle and normal cells lab A&B: Sickle Cell NYT: A&B: This American Life “Bad Cell Service” A&B: Gene therapy for hemophilia A&B: Throughline podcast sickle cell (19:30-25:10) A&B: This Podcast will Kill You
Sickle cell patient's success with gene editing raises hopes and questions Scitable: DNA is constantly changing… A&B: We are all mutants (questions) A&B: Mutations you want A&B: Double edged genes reading A&B: Uncommon Carriers A&B: White Tiger Mutation A&B: The DIY Scientist, the Olympian, and the Mutated Gene A&B: eople With This Mutation Can’t Smell Stinky Fish Girl with deadly inherited condition is cured with gene therapy on NHS In Chernobyl’s Stray Dogs, Scientists Look for Genetic Effects of Radiation - The New York Times Animal Mutation Rates Reveal Traits That Speed Evolution
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| 4 | Genomes | 3.1.U6: The genome is the whole of the genetic information of an organism
3.2.A2: Comparison of genome size in T2 phage, Escherichia coli, Drosophila melanogaster, Homo sapiens, Paris japonica
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Reading: smallest genome ever (questions) Reading: largest genome |
| 5 | Sequencing and the HGP | 3.1.U7: The entire base sequence of human genes was sequenced in the Human Genome Project
3.1.NOS: Developments in scientific research follow improvements in technology-gene sequencers are used for the sequencing of genes
7.1.A3: Use of nucleotides containing dideoxyribonucleic acid to stop DNA replication in preparation of samples for base sequencing
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Scitable: The order of nucleotides in a gene... (sometimes done in the cladistics unit) Pronouncing the Human Genome (satire) A&B: Economic Return of the HGP (questions) A&B: Should babies be sequenced (questions) Sequencing projects will screen 200,000 newborns for disease genes | Science | AAAS From Alpacas to Yaks, Mammal DNA Yields Its Secrets - The New York Times What Cheetahs, Armadillos and Whales Revealed About Human DNA |
| 6 | Mystery Genes | 3.2.S1: Use of databases to identify the focus of a human gene and its polypeptide product
3.1.S1: Use of a database to determine differences in the base sequence of a gene in two species.
7.3.NOS: Developments in scientific research follow improvements in computing- the use of commuters has enabled scientists to make advances in bioinformatics applications such as locating genes within genomes and identifying conserved sequences.
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Electropherograms for mystery genes |
| 7 | Wrap Up and Review | ||